Scientific work

Scientific work of the Department

Scientific program of the Department:
1. Molecular basis of secondary immune deficiencies and ways of their correction.
2. The molecular mechanisms of injury of biological membranes.
3. Synthesis of biologically active compounds based on complexes with ligands of nutrients.
During the last 5 years at the department were published 2 monographs, 16 teaching aids, as well as guidance and newsletters.

Monographs published in the last 5 years

 

Title

Author

Edition

Year of publication,page

1.

Biologik sistemalarda kislorodning Erkin radikallarning tasiri wa HIMOYA mehanizmlari
(in Uzbek. language)

Soatov TS,
Ibragimov WC,
Khaibullina ZR

Publishing Department TashPMI
700140, Tashkent, Abidova J., 223

2009
Pp. 1-80

2.

Biological membranes
(in Russ. language)

Ibragimov WC,
Khaibullina ZR

Publishing Department TashPMI
700140,Tashkent Abidova J., 223

2009
Pр. 1-134

3

Effects of active oxygen species and antioxidants

(in Russ. language)

Nazirov FG, Ibragimov UK, Khaibullina ZR

Published by:

LAP LAMBERT Academic Publishing

ist ein Imprint der / is a trademark

OmniScriptum GmbH & Co.KG

I leinrich-Bficking-Str. 6-8, 66121 Saarbriicken, Deutschland / Germany

2014,

Рр.1-100

Of these, the main ones are the following journal articles:Employees of the Department widely publish the results of their research in leading peer-reviewed journals and books, including the top-rated domestic scientific journals such as "The Medical Journal of Uzbekistan", "Pathology", "Infection, Immunity and pharmacology", "Pediatrics", "biochemistry. "

Employees of the department are involved and make presentations at national and international conferences.

Of these, the main ones being the following journal articles:

Scientific publications of the Department

2017 year

1. Khaybullina ZR. Synthetic Antioxidants and Its Effects in Ultra Low Concentrations, Probability of Cardio Protection by Membrane Stabilization // Journal of Cardiology & Cardiovascular Therapy. № 4(5), 2017, рр. 1-2. (article, Europe).

2. Nishantaev MK, Yuldashev NM, Kamolova AA, Atavullaeva MA. The hypolipidemic property of a substance based on silk fibroin // Journal of Young Scientist. No. 13 (147), Part II, 2017, рр. 139-141. (article, CIS).

3. Akbahodzhayeva Kh.N., Alimkhodzhaeva NT, Muzaffarhonov Sh.M. The content of phospholipids in immunocompetent cells of experimental rats // Journal of Young Scientist. No. 16 (150), Part I, 2017, рр. 5-7. (article, CIS).

4. Ismailova GO, Yuldashev NM, Rakhimova GR, Harisova I.I. Contribution of the nucleus and substituents of synthesized derivatives of 2'-substituted chalcons to the activity of substances with regard to their position // Journal of Almanac of Modern Science and Technology Education, No. 2 (116), 2017, pp. 55-60. (article, CIS).

5. Akbarhodzhaeva Kh.N., Alimkhodzhaeva NT, Minavarova Sh.A., Bizhanova AB. The change in the phospholipid (PL) composition of the liver and immunocompetent organs of rats during xenobiotic intoxication // Journal of Young Scientist. No. 16 (150), Part I, 2017, рр. 1-5. (article, CIS).

6. Ziyamutdinova ZK, Akbarkhodzhaeva Kh. N., Yuldashov SI, Masharipov I.O. Correcting effect of membrane stabilizers and antioxidants // Journal of Young Scientist. No. 14 (148), Part III, 2017, pp. 225-227. (article, CIS).

7. Karimova Sh.F., Yuldashev NM, Ismayilova GO, Nozimshiniyeva MA. Sensitivity of thyroidocytes of growing rats to thyroid-stimulating hormone of pituitary gland with different iodine maintenance // Journal of Pediatrics. № 1, 2017, pр.138-139. (article, L).

8. Ismailova G.O. Pedagogical innovative technology of a subject of biochemistry on the basis of modular training // "Application and efficiency of modern technologies in the higher medical education" Republican educational-methodical conference. Collection of articles and abstracts. January 6, 2017. TashPMI. Tashkent. Pp. 228-235. (article, L).

9. Ismailova GO, Yuldashev NM. Application and effectiveness of modern technologies in higher medical education of independent work of students on modular training // "Application and efficiency of modern technologies in higher medical education" Republican educational-methodical conference. Collection of articles and abstracts. January 6, 2017. TashPMI. Tashkent. pp. 235-240. (article, L).

10. Ziyamutdinova ZK, Akbarhodzhaeva Kh.N., Janalieva G.A. "Eritmalarni tibbyotdagi ahamiyati" Mavzusini pedagogy tekhnolar vositasida tashkil kilish // "Application and efficiency of modern technologies in higher medical education" Republican educational and methodical conference. Collection of articles and abstracts. January 6, 2017. TashPMI. Tashkent. Pp. 201-203. (article, L).

11. Ismailova G.O., Suleymanova G.G., Madiev Yu.R. Classical method of quantitative determination of the total amount of biologically active coumarinic components in the plant organs of white melon // Periodical scientific collection "Modern trends in the development of science and technology" based on the materials of the XXII International Scientific and Practical Conference, Belgorod, January 31, 2017, No. 1, part 2, pp. 70-72. (thesis, CIS).

12. Ismailova GO, Bakhodirova M.O. Biological activity of 3-amino, 6-fluoro-3 ', 4'-ethylenedioxyflavone // "Trends and innovations of modern science" materials of the XIX International Scientific and Practical Conference (March 29, 2017). Theses of reports, Krasnodar. p. 30. (Thesis, CIS).

13. Ismailova GO, Solibaeva NO, Eldosheva P.Zh. Hepatoprotective activity of 3-amino, 6-fluoro-3', 4'-ethylenedioxyflavone. // "Trends and Innovations of Modern Science" materials of the XIX International Scientific and Practical Conference (March 29, 2017). Theses of reports, Krasnodar. 29. (Thesis, CIS).

14. Ismailova GO, Makhammadkosimova ZB. Cytoprotective activity of 3-amino, 6-chloro-3', 4'-ethylenedioxyflavone // // "Trends and Innovations of Modern Science" materials of the XIX International Scientific and Practical Conference (29 March 2017). Theses of reports, Krasnodar. С. 28. (Thesis, CIS). 

Dissertations

Over the past period made one doctoral dissertation.
Khaibullina Zarina Ruslanovna in 2012 defended his doctoral thesis at the Institute of Biochemistry, Academy of Sciences of Uzbekistan in Tashkent on "Molecular mechanisms of damage biomembranes under the reactive oxygen species during hypoxia." Specialty code 03.00.04 - Biochemistry. A 015.16.01. Scientific Director - Doctor of Medicine, Professor Ibrahim WC
The results obtained and their novelty: in the late periods posthypoxic period set mezhorgannaya relationship of the brain and liver, and its contribution to the worsening effects of cerebral ischemia. Set contribution excess generation of ROS and violations of phospholipid content in the mitochondrial fraction of liver in the development of apoptosis of hepatocytes in posthypoxic period and anti-apoptotic effect nanodoz fenozana, established part of the membrane component of the microsomal fraction of the liver in posthypoxic adaptive reactions and nanodoz modulating effect of alpha-tocopherol on antioxidant enzyme system (AOS ) in early posthypoxic period. Set primary effect of synthetic water-soluble antioxidant nanodoz fenozana in brain tissue by enzymatic chain EPA with further reduction of oxidized phospholipids and optimization of conditions for the development of the brain.
Practical value: prognostic severity scale developed cerebral ischemia neonatal nanodoz justified use of antioxidants in experimental fetal hypoxia.
The degree of implementation and cost-effectiveness: the obtained results are introduced in the form of guidelines and information letter in RSNPMTS Pediatrics RSNPMTS Obstetrics and Gynecology, and TIAME TashPMI.
Scope: biochemistry, pediatrics.

Cooperation Department

The scientific work of the department is working closely with the Department of Biochemistry of TMA, Department of Clinical and laboratory TIAME, Institute of Bioorganic Chemistry of the Republic of Uzbekistan., The Institute of Biochemical Physics, Russian Academy of Sciences (Moscow), the Department of Biochemistry of Urgench branch of TMA.

Grants, membership in scientific organizations and editorial boards

From 2012 to 2014, the Department is working on a grant ADSS 30.3 "Development of a method of enhancing the healing of myocardial necrotic lesions in the experiment ," Head - prof . NM Yuldashev .
Scientific authority of the department confirmed that Academician TS Saatov for 10 years headed the Specialized Council D 015.16.01 for doctoral and master's theses at the Institute of Biochemistry , Academy of Sciences of Uzbekistan , Professor NM Yuldashev to 2012 he was scientific secretary of the Joint Council Divisional D 087.09.02 TMA for doctoral and master's theses , currently is a member of Ed. board of the journal "Cardiology Uzbekistan" , expert of Ministry of Health and the Uzbek Academy of Sciences , member of the Advisory Board for the examination of textbooks and teaching aids Ministry of Higher Education . Currently, members of the department Acad. TS Saatov is a member of the Specialized Council 03.00.01 , biochemistry , biophysics and radiobiology at the Institute of Bioorganic Chemistry, Prof. . NM Yuldashev MD ZR Khaibullina are members of the Divisional Council 17. 4 - Pathological physiology , forensic medicine and hygiene at TMA, And ZR Haibullina - the Chairman of problem Commission of Tashkent pediatric medical Institute for medico-biological disciplines.

                                                        Inventions
Implemented in practical public health 1 patent, 5 methodical recommendations, 3 newsletters, 1 improvement suggestion.

 

Name

Form

Issue

Аuthors

1

Way of modeling allergic myocarditis

Patent

№ 5776
29.04.

1999

Karimov H.YA.,
Rakhmatullayev SS,
YuldashevNM

2

New model
Play nephrolithiasis

Methodical recommendation

Tashkent, 2000.  8р.

Karimov H.YA.,
Shakirov DS,
YuldashevNM

3

Remedy hepato-renal failure in crush syndrome in the prepubertal period

Newsletter

Tashkent, 2002. 3р.

Rakhmatullayev FH,
Yuldashev NM
Khakimov ZZ

4

A way to restore the hepatic blood flow in crash - syndrome in prepubertal period

Newsletter

Tashkent, 2002. 3р.

Rakhmatullayev FH,
Yuldashev NM
Khakimov ZZ

5

Methodological approaches to the modeling of myocardial necrosis in rats

Methodical recommendations

Tashkent, 2004.  6р.

Azizov A. S.,
Karimov H. J.,
YuldashevNM

6

Modeling metabolic   a ches who syndrome in rabbits.

Methodical recommendations

Tashkent, 2006. 11p.

Karimov H. J.,
Mukhammedov JA,
Yuldashev, NM
Saidov SA

7

Modern aspects of the metabolic syndrome.

Methodical recommendations

Tashkent, 2006. 28p.

Karimov H. J.,
Yuldashev, NM
Mukhammedov JA,
Guriev SB,
Saidov SA

8

Separation Methods of experimental animals individually - metabolic characteristics of the organism

Methodical recommendations

Tashkent, 2006. 21 p

Saidov AB,
Yuldashev, NM
Iriskulov BU

9

A method of predicting the risk of hypoxic-ischemic brain damage in newborn

Rat. offer

certificate

№ 82
6.03. 2012

Khaibullina ZR

10

The effectiveness of glycine in the correction of abnormalities in myocardial infarction.

 

Newsletter.

The beetle. No. 10-1493, "Extremum-Press", TSK, street Bogishamol b
Tashkent pediatric medical Institute. Tashkent - 2014, S. 1-4.

Yuldashev N. M., Ismailovа G O., Karimovа Sh. F., Nishantaev K. M.

 

                                       Student Scientific Society Chair

Department operates on Students' Scientific Society and the circle "Young biochemist." SSS members are actively engaged in scientific work, published abstracts of papers at the institute TashPMI, at national and international conferences SSS. Scientific Activities of the circle "Young biochemist": free-radical processes in the body in different diseases.

Scientific publications of Students' Scientific Society

2017 year

 

1. Bakhodirova M.O., 211 - group, II - pediatric faculty. Scientific adviser: Ismailova G.O. Flavonoidal medicinal plant of Uzbekistan // "Khalk bilan mulokot wa inson manfaatlari iili" ha bahishlangan Talabalar ilmiye jamiyatining 45 - ilmiy - amaliy anzhumani tezislar with muds. Tashkent, April 20, 2017. P. 90. (Thesis, M).

2. Harisova I.I., 313 - group, I - pediatric faculty. Scientific adviser: Ismailova G.O. Bioscreening of the synthesized chalcon derivative // "Khalk bilan mulokot wa inson manfaatlari iili" ha bahishlangan Talabalar ilmiye jamiyatining 45 - ilmiy - amaliy anzhumani tezislar with muds. Tashkent,  April 20, 2017. S. 475. (Thesis, M).

3. Kamolova A.A., 212 - group, II - pediatric faculty. Scientific adviser: Yuldashev N.M. Analysis of the absorption capacity of the preparation based on silk fibroin, taking into account its molecular structure. // "Khalk bilan mulokot wa inson manfaatlari iili" ha bahishlangan Talabalar ilmiye jamiyatining 45 - ilmiy - amaliy anzhumani tezislar with muds. Tashkent, April 20, 2017. P. 191. (thesis, M).

4. Atavullaeva M.A., 212 - group, II - pediatric faculty. Supervisor: Nishantaev M.K. A study of the absorption capacity of a preparation based on silk fibroin in relation to cholesterol // "Khalk bilan mulokot wa inson manfaatlari iili" ha bahishlangan Talabalar ilmiye jamiyatining 45 - ilmiy - amaliy anzhumani tezislar with muds. Tashkent, April 20, 2017. S. 84. (thesis, M).

5. Madiev Yu.R., 206 - group, medical-pedagogical faculty and medical business. Supervisor: Karimova Sh.F. Morphological changes in the thyroid gland of suckling suckers after the thyroidectomy of the lactating rat // "Khalk bilan mulokot wa inson manfaatlari iili" ha bahishlangan Talabalar ilmiye jamiyatining 45 - ilmiy - amaliy anzhumani tezislar with muds. Tashkent,  April 20, 2017. S. 233. (thesis, M).

6. Kamalova N.N., 210 - group, I - pediatric faculty. Scientific adviser: Ziyamutdinova Z.K. The importance of phospholipids and gangliosides as structural units of membranes // "Khalk bilan mulokot wa inson manfaatlari iili" ha bahishlangan Talabalar ilmiye jamiyatining 45 - ilmiy - amaliy anzhumani tezislar with muds. Tashkent, April 20, 2017. S. 196. (thesis, M).

 

 

In 2017 SSS conferences were published more than 20 students' works (local and foreign publications).

Curator Mug -  Dotsent Nishantaev MK

• Publishing of student works in scientific materials (see: Downloads)