ФОТОДИНАМИЧЕСКАЯ ТЕРАПИЯ — ИННОВАЦИОННЫЙ МЕТОД БОРЬБЫ С АНТИБИОТИКОРЕЗИСТЕНТНЫМИ БАКТЕРИЯМИ В ХИРУРГИИ

Турсуметов А.А., Ташкентский педиатрический медицинский институт

Исаков Ш.Ш. Ташкентский педиатрический медицинский институт

Resume

The article considers the issues of microbiological substantiation of the bactericidal action of photodynamic therapy using the methylene blue photosensitizer against to the microflora of the bronchial tree in the experiment in vitro. In the experiment, the inhibition of the growth of microbial strains under the action of laser radiation in the red range with a wavelength of 630 nm was determined. Optimal modes of action and exposure of photodynamic antibiotic therapy have been established. The maximum antibacterial effect of PDT against bacteria was achieved using a 0.05% aqueous solution of MB. Used microbiological, statistical research methods.

Keywords: antibiotic-resistant bacteria, photodynamic therapy, photosensitizer, methylene blue

Первая страница
33

Последняя страница
39

Для цитирования

Турсуметов А.А., Исаков Ш.Ш. ФОТОДИНАМИЧЕСКАЯ ТЕРАПИЯ — ИННОВАЦИОННЫЙ МЕТОД БОРЬБЫ С АНТИБИОТИКОРЕЗИСТЕНТНЫМИ БАКТЕРИЯМИ В ХИРУРГИИ // Евразийский вестник педиатрии. — 2022; 2 (13): 33-39. https://clck.ru/hcm58

Литература

  1. 1. Adarchenko A.A., Krasilnikov A.P., Nikolaev N.E. Comparative activity of anitiotics and antiseptics in a sample of Enterobacteriaceae spp . //Health care of Belarus. -1992.-№6.-S.35-40.
  2. 2. Afinogenov G.E., Blinov N.E. Antiseptics in surgery. L.: Medicine. 1987.-144 p.
  3. 3. V.P. Bulavkin , V.K. Okulich, V.Yu. Zemko . Rational antibiotic therapy in surgery and intensive care // Vitebsk. — 2019.-p.63.
  4. 4. Burnevich S.Z. , Brazhnik T.B. Antibacterial therapy of abdominal surgical infections. «RMJ» No. 8 dated 04/17/2002 p. 400.
  5. 5. Ibadov R.A., Shanieva Z.A., Arifzhanov A.Sh., Eshonkhodzhaev O.D., Strizhkov N.A., Komirenko P.G., Mansurov Z.N. Original biotechnologies in the prevention and treatment of bronchopulmonary complications in patients on prolonged ventilation. Journal of Microbiology Research 2014, 4(1): 14-17 DOI : 10.5923/ j . Microbiology .20140401.03.
  6. 6. Stranadko E.F., Geinits A.V., Volgin V.N. et al . Clinical and socio-economic evaluation of photodynamic therapy for cancer and non-tumor diseases//Laser medicine. -2015.-T.19.-No.2.-S.37-41.
  7. 7. Shek E.A., Sukhorukova M.V., Eidelstein M.V. et al . Antibiotic resistance, carbapenemase production and genotypes of nosocomial strains of Acinetobacter spp .in Russian hospitals: results of the multicenter epidemiological study «Marathon 2015-2016» // Clinical Microbiology and Antimicrobial Chemotherapy. — 2019. — T. 21. — No. 2. — S. 178-187.
  8. 8. Boucher HW, et al. Clin Infect Dis. 2009; 48:1.
  9. 9. Peterson L.R. Clin Infect Dis. 2009; 49(6): 992-3.
  10. 10. Zakhidov E.A., Kokhkharov A.M., Nematov Sh.Q. _ (2011). Effect of molecular surrounding to spectral characteristics of chlorophylls – the perspective PDT photosensitizers // Uzbek Journal of physics. 13, No3. 160-168.
  11. 11. Rice L.B. J Infect Dis. 2008; 197:1079.
  12. 12. Wainwright V. (1998). Photodynamic antimicrobial chemotherapy (PACT). Journal of Antimicrobial Chemotherapy. 42, 13–28.

Статья доступна ниже:

Скачать PDF